Abstract
Estrogen-mediated proliferation is fundamental to normal mammary gland development. Recent studies have demonstrated that amphiregulin is a critical paracrine regulator of estrogen action during ductal morphogenesis. These studies implicate a critical role for amphiregulin in mammary stem cell differentiation as well as breast cancer initiation and progression.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Amphiregulin
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Breast / growth & development*
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Breast / pathology
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Breast Neoplasms / etiology*
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Breast Neoplasms / pathology
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EGF Family of Proteins
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Estrogens / pharmacology*
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Glycoproteins / metabolism*
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Humans
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Intercellular Signaling Peptides and Proteins / metabolism*
Substances
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AREG protein, human
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Amphiregulin
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EGF Family of Proteins
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Estrogens
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Glycoproteins
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Intercellular Signaling Peptides and Proteins