Abstract
SDF-9 is a modulator of Caenorhabditis elegans insulin/IGF-1 signaling that may interact directly with the DAF-2 receptor. SDF-9 is a tyrosine phosphatase-like protein that, when mutated, enhances many partial loss-of-function mutants in the dauer pathway except for the temperature-sensitive mutant daf-2(m41). We propose that SDF-9 stabilizes the active phosphorylated state of DAF-2 or acts as an adaptor protein to enhance insulin-like signaling.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Animals, Genetically Modified
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Caenorhabditis elegans / genetics*
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Caenorhabditis elegans / growth & development
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Caenorhabditis elegans / metabolism
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Caenorhabditis elegans Proteins / genetics
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Caenorhabditis elegans Proteins / metabolism*
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Hypoglycemic Agents / pharmacology
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Insulin / pharmacology*
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Insulin-Like Growth Factor I / metabolism*
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Mutation / genetics
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Pheromones / pharmacology
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Phosphorylation
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Protein Tyrosine Phosphatases / genetics
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Protein Tyrosine Phosphatases / metabolism*
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Receptor, Insulin / genetics
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Receptor, Insulin / metabolism*
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Signal Transduction*
Substances
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Caenorhabditis elegans Proteins
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Hypoglycemic Agents
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Insulin
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Pheromones
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Insulin-Like Growth Factor I
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DAF-2 protein, C elegans
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Receptor, Insulin
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Protein Tyrosine Phosphatases
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SDF-9 protein, C elegans