With an incidence of nearly 1%, epilepsy represents one of the most frequent diseases in the population. Nevertheless substantial information gaps exist as to the exact incidence, prevalence, therapy and particularly to associated therapeutic success. Adequate studies are not performed on many of these issues which are primarily beyond the current interests of the pharmaceutical industry. An Internet-based knowledge management database is presented to illustrate initial results of the online system with a focus on medication and side effects (http://www.ligaepilepsie.org/KnowledgeDB/index.htm). Further, it is worth noting that this database was designed as a potential model for similar projects in other medical fields.