Abstract
Galanthamine is an alkaloid approved for the treatment of Alzheimer's disease. In this paper the syntheses and the anticholinesterase activities of new glucosyl and nitroxy derivatives substituted on position 6 are reported. Compounds 2, 3 and 5 presented a percentage of inhibition of 35.22%, 47.48% and 67.89% respectively.
MeSH terms
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Animals
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Brain / drug effects
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Brain / enzymology
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Cholinesterase Inhibitors / chemical synthesis*
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Cholinesterase Inhibitors / pharmacology*
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Chromatography, High Pressure Liquid
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Galantamine / analogs & derivatives*
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Galantamine / chemical synthesis
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Galantamine / pharmacology*
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In Vitro Techniques
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Indicators and Reagents
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Magnetic Resonance Spectroscopy
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Male
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Molecular Conformation
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Rats
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Rats, Sprague-Dawley
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Stereoisomerism
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Structure-Activity Relationship
Substances
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Cholinesterase Inhibitors
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Indicators and Reagents
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Galantamine