Abstract
This study compares beta-lactam and vancomycin among intravenous drug users with infective endocarditis caused by methicillin-susceptible Staphylococcus aureus. Patients who received vancomycin had higher infection-related mortality, even if they were switched to beta-lactam once culture results became available; this relationship persisted after logistic regression analysis controlling for clinical characteristics.
MeSH terms
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Adult
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Anti-Bacterial Agents / pharmacology*
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Cohort Studies
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Endocarditis, Bacterial / complications*
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Endocarditis, Bacterial / drug therapy*
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Female
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Humans
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Male
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Methicillin / pharmacology*
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Microbial Sensitivity Tests
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Middle Aged
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Retrospective Studies
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Staphylococcal Infections / drug therapy*
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Staphylococcal Infections / microbiology
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Staphylococcus aureus / drug effects*
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Substance Abuse, Intravenous / complications*
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Treatment Outcome
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Vancomycin / therapeutic use
Substances
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Anti-Bacterial Agents
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Vancomycin
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Methicillin