Abstract
Antiretroviral drug therapy and cytotoxic T lymphocytes (CTL) both exert selective pressures on human immunodeficiency virus type 1, which influence viral evolution. Compared to chronically infected, antiretroviral-untreated patients, most chronically infected, treated patients with detectable viremia lack a cellular immune response against the Gag 77-85(SL9) epitope but show a new immunodominant response against an epitope in protease PR 76-84. Hence, mutations induced by antiretroviral therapy likely alter the profile of epitopes presented to T cells and thus the direction of the response. The consequences of dual pressures from treatment and CTL need to be considered in monitoring of drug therapy.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Retroviral Agents / pharmacology*
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Gene Products, gag / immunology*
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Gene Products, pol / immunology*
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HIV-1 / genetics
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HIV-1 / immunology*
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Humans
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Immunity, Cellular / drug effects*
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Immunodominant Epitopes
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Molecular Sequence Data
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Mutation
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Selection, Genetic
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T-Lymphocytes, Cytotoxic / drug effects
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T-Lymphocytes, Cytotoxic / immunology*
Substances
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Anti-Retroviral Agents
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Gene Products, gag
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Gene Products, pol
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Immunodominant Epitopes
Associated data
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GENBANK/EU011832
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GENBANK/EU011833
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