Children's emotion dysregulation and maternal scaffolding at age 4 were examined as predictors of social skills at age 6, for 66 children with and 106 without early developmental delays. Observed scaffolding and regulation during frustrating laboratory tasks related to later mother, father, and teacher social-skill ratings for children with delays and were stronger predictors of social skills within this group than were developmental level and early behavior problems. In contrast, fewer associations were found for typically developing children, with early behavior problems providing the only unique prediction to social skills. Data support a model in which dysregulation partially mediates the association between developmental status and social-skill outcomes. Implications for research, prevention, and early intervention are discussed.