Abstract
Juzen-taiho-to (JTT; [Shi-quan-da-bu-tang], a Japanese modified Chinese herbal prescription) in combination with an anticancer drug UFT (5-fluorouracil derivative) prevented the body weight loss and the induction of the colonic cancer in rats treated with a chemical carcinogen 1,2-dimethylhydrazine (DMH), and suppressed markedly the activity of thymidylate synthetase (TS) involved in the de novo pathway of pyrimidine synthesis in colonic cancer induced by DMH.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adenocarcinoma / drug therapy*
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Adenocarcinoma / enzymology
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Adenocarcinoma / pathology
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Animals
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Antineoplastic Combined Chemotherapy Protocols / administration & dosage
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Antineoplastic Combined Chemotherapy Protocols / pharmacology
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
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Colonic Neoplasms / drug therapy*
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Colonic Neoplasms / enzymology
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Colonic Neoplasms / pathology
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Drug Evaluation, Preclinical
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Drugs, Chinese Herbal / administration & dosage*
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Fluorouracil / administration & dosage*
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Neoplasm Staging
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Rats
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Thymidine Kinase / drug effects
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Thymidylate Synthase / drug effects*
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Weight Loss / drug effects
Substances
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Drugs, Chinese Herbal
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juzentaihoto
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Thymidylate Synthase
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Thymidine Kinase
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Fluorouracil