Abstract
A 49 year old white woman with systemic lupus erythematosus and bronchiolitis obliterans was treated with prednisone (1 mg/kg daily), which led to a transitory improvement in pulmonary status. Cyclophosphamide was then added--4 mg/kg daily intravenously for five days, then 2 mg/kg daily orally--and this was followed by a dramatic and prolonged improvement.
MeSH terms
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Administration, Oral
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Bronchiolitis Obliterans / complications
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Bronchiolitis Obliterans / drug therapy*
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Cyclophosphamide / administration & dosage*
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Cyclophosphamide / therapeutic use
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Drug Therapy, Combination
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Female
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Humans
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Injections, Intravenous
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Lupus Erythematosus, Systemic / complications*
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Lupus Erythematosus, Systemic / drug therapy
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Middle Aged
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Prednisolone / therapeutic use
Substances
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Cyclophosphamide
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Prednisolone