Amebic liver abscess is an emergent disease in Spain due to immigration and travel to endemic countries. Although mainly pharmacological, treatment can sometimes require drainage, especially when there is a high risk of rupture due to location or size. We report a case of amebic liver abscess that, due to its large size and lack of response to metronidazole therapy, required percutaneous drainage. This technique, with ultrasound-guided percutaneous aspiration, would be indicated in lesions with a diameter of > 5 cm, abscesses of the left lobe, and those unresponsive to medical treatment.