Prediction of protein-ligand complex structure by docking software guided by other complex structures

J Mol Graph Model. 2008 Feb;26(6):1030-3. doi: 10.1016/j.jmgm.2007.07.001. Epub 2007 Jul 12.

Abstract

We developed a new scoring method that selects a protein-ligand complex structure with higher geometrical accuracy than the top-scoring complex structure, using the structural information of known protein-ligand complexes. To apply this method, one or more protein-ligand complex structures must be known for the target protein. A number of predicted structures were generated by the protein-compound docking program for a new ligand, and one of these structures, which showed the maximum overlap with the ligand coordinates of the known protein-ligand complex, was selected as the most probable complex structure.

MeSH terms

  • Binding Sites
  • Ligands
  • Predictive Value of Tests
  • Protein Binding*
  • Protein Interaction Mapping*
  • Proteins / chemistry*
  • Proteins / metabolism*
  • Software*
  • Thermodynamics

Substances

  • Ligands
  • Proteins