Abstract
A pentasaccharide that contains the alpha-1,4-GlcNAc mucin core two-branched O-glycan has been synthesized by a one-pot, two-step glycosylation strategy; this particular carbohydrate motif may provide protection against H. pylonri induced pathologies since the synthetic pentasaccharide inhibits cholesterol alpha-glucosyltransferase (IC50 of 0.47 mM).
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Anti-Bacterial Agents / chemical synthesis*
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology
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Carbohydrate Sequence
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Enzyme Activation / drug effects
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Glucosyltransferases / antagonists & inhibitors
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Glucosyltransferases / chemistry
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Glycosylation
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Helicobacter pylori / enzymology
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Molecular Sequence Data
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Oligosaccharides / chemical synthesis*
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Oligosaccharides / chemistry
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Oligosaccharides / pharmacology
Substances
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Anti-Bacterial Agents
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Oligosaccharides
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Glucosyltransferases
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Hp0421 protein, Helicobacter pylori