The human homolog of the mouse brown gene maps to the short arm of chromosome 9 and extends the known region of homology with mouse chromosome 4

Genomics. 1991 Oct;11(2):471-3. doi: 10.1016/0888-7543(91)90160-g.

Abstract

The mouse brown locus encodes a tyrosinase-related protein, TRP-1. The human homolog of TRP-1 was recently cloned from a melanoma cDNA library and sequenced. We have made oligonucleotide primers corresponding to the human TRP1 3' untranslated region and used them to map the human TRP1 gene by species-specific PCR in human/rodent somatic cell hybrids. By this means, the human TRP1 gene has been mapped to the short arm of chromosome 9.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Bacterial Proteins / genetics*
  • Base Sequence
  • Chromosome Mapping
  • Chromosomes, Human, Pair 9*
  • DNA-Binding Proteins*
  • Gene Library
  • Humans
  • Hybrid Cells
  • Melanoma / genetics
  • Mice / genetics*
  • Molecular Sequence Data
  • Polymerase Chain Reaction
  • Trans-Activators*

Substances

  • Bacterial Proteins
  • DNA-Binding Proteins
  • Trans-Activators