Influence of CYP2C19 and CYP3A4 gene polymorphisms on clopidogrel responsiveness in healthy subjects

J Thromb Haemost. 2007 Oct;5(10):2153-5. doi: 10.1111/j.1538-7836.2007.02722.x. Epub 2007 Aug 3.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • Aryl Hydrocarbon Hydroxylases / genetics*
  • Clopidogrel
  • Cytochrome P-450 CYP2C19
  • Cytochrome P-450 CYP3A
  • Cytochrome P-450 Enzyme System / genetics*
  • Genotype
  • Humans
  • Mixed Function Oxygenases / genetics*
  • Mutation
  • Platelet Adhesiveness
  • Platelet Aggregation Inhibitors / pharmacology*
  • Platelet Function Tests
  • Polymorphism, Genetic*
  • Protein Isoforms
  • Regression Analysis
  • Ticlopidine / analogs & derivatives*
  • Ticlopidine / pharmacology
  • Time Factors
  • Treatment Outcome

Substances

  • Platelet Aggregation Inhibitors
  • Protein Isoforms
  • Cytochrome P-450 Enzyme System
  • Clopidogrel
  • Mixed Function Oxygenases
  • Aryl Hydrocarbon Hydroxylases
  • CYP2C19 protein, human
  • Cytochrome P-450 CYP2C19
  • Cytochrome P-450 CYP3A
  • CYP3A4 protein, human
  • Ticlopidine