Abstract
Inorganic phosphate (Pi) plays a key role in diverse physiological functions. Several studies indicate that Pi may affect lung cell development through Na/Pi cotransporter (NPT). Several NPT subtypes have been identified in mammalian lung, and considerable progress has been made in our understanding of their function and regulation. Therefore, current study was performed to elucidate the potential effects of high dietary Pi on lungs of developing mice. Our results clearly demonstrate that high dietary Pi may affect the lung of developing mice through Akt-related cap-dependent protein translation, cell cycle regulation, and angiogenesis. Our results support the hypothesis that Pi works as a critical signal molecule for normal lung growth and suggest that careful restriction of Pi consumption may be important in maintaining a normal development.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adaptor Proteins, Signal Transducing
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Animals
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Carrier Proteins / metabolism
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Cell Cycle / drug effects*
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Cell Cycle Proteins / metabolism
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Cell Proliferation / drug effects
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Dose-Response Relationship, Drug
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Eukaryotic Initiation Factors
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Fibroblast Growth Factor 2 / metabolism
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Lung / blood supply
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Lung / drug effects*
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Lung / growth & development
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Lung / metabolism
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Lung / pathology
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Matrix Metalloproteinase 2 / metabolism
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Mice
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Mice, Transgenic
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Neovascularization, Physiologic / drug effects*
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Phosphoproteins / metabolism
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Phosphorus, Dietary / administration & dosage*
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Phosphorylation
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Protein Biosynthesis / drug effects*
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Protein Kinases / metabolism
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Proto-Oncogene Proteins c-akt / metabolism
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RNA Cap-Binding Proteins / genetics
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RNA Cap-Binding Proteins / metabolism
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Signal Transduction / drug effects*
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Sodium-Phosphate Cotransporter Proteins, Type IIb / metabolism
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TOR Serine-Threonine Kinases
Substances
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Adaptor Proteins, Signal Transducing
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Carrier Proteins
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Cell Cycle Proteins
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Eif4ebp1 protein, mouse
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Eukaryotic Initiation Factors
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Phosphoproteins
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Phosphorus, Dietary
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RNA Cap-Binding Proteins
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Sodium-Phosphate Cotransporter Proteins, Type IIb
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Fibroblast Growth Factor 2
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Protein Kinases
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mTOR protein, mouse
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Proto-Oncogene Proteins c-akt
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TOR Serine-Threonine Kinases
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Matrix Metalloproteinase 2