Abstract
A variety of fiber types with different contractile and metabolic properties is present in mammalian skeletal muscle. The fiber-type profile is controlled by nerve activity via specific signaling pathways, whose identification may provide potential therapeutic targets for the prevention and treatment of metabolic and neuromuscular diseases.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Calcineurin / physiology
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Diabetes Mellitus, Type 2 / physiopathology
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Humans
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Mice
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Muscle Contraction / physiology
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Muscle, Skeletal / physiology*
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Muscular Dystrophies / physiopathology
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NFATC Transcription Factors / physiology
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Peroxisome Proliferator-Activated Receptors / physiology
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Rats
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Signal Transduction / physiology*
Substances
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NFATC Transcription Factors
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Peroxisome Proliferator-Activated Receptors
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Calcineurin