Age-dependent association of KIBRA genetic variation and Alzheimer's disease risk

Eloy Rodríguez-Rodríguez; Jon Infante; Javier Llorca; Ignacio Mateo; Coro Sánchez-Quintana; Inés García-Gorostiaga; Pascual Sánchez-Juan; José Berciano; Onofre Combarros

doi:10.1016/j.neurobiolaging.2007.07.003

Age-dependent association of KIBRA genetic variation and Alzheimer's disease risk

Neurobiol Aging. 2009 Feb;30(2):322-4. doi: 10.1016/j.neurobiolaging.2007.07.003. Epub 2007 Aug 17.

Authors

Eloy Rodríguez-Rodríguez¹, Jon Infante, Javier Llorca, Ignacio Mateo, Coro Sánchez-Quintana, Inés García-Gorostiaga, Pascual Sánchez-Juan, José Berciano, Onofre Combarros

Affiliation

¹ Neurology Service, Marqués de Valdecilla University Hospital, University of Cantabria, Santander, Spain.

PMID: 17707552
DOI: 10.1016/j.neurobiolaging.2007.07.003

Abstract

An association between memory performance in healthy young, middle aged an elderly subjects and variability in the KIBRA gene (rs17070145) has been recently described. We analyzed this polymorphism in 391 sporadic Alzheimer's disease (AD) patients and 428 cognitively normal control subjects. The current study reveals that KIBRA (rs17070145) T allele (CT and TT genotypes) is associated with an increased risk (OR 2.89; p=0.03) for very-late-onset (after the age of 86 years) AD.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aged
Aged, 80 and over
Aging / genetics*
Alzheimer Disease / epidemiology*
Alzheimer Disease / genetics*
Female
Genetic Predisposition to Disease / epidemiology
Genetic Predisposition to Disease / genetics
Genetic Variation / genetics
Humans
Incidence
Intracellular Signaling Peptides and Proteins
Male
Middle Aged
Phosphoproteins
Polymorphism, Single Nucleotide / genetics*
Proteins / genetics*
Risk Assessment / methods*
Risk Factors
Spain / epidemiology

Substances

Intracellular Signaling Peptides and Proteins
Phosphoproteins
Proteins
WWC1 protein, human