Abstract
Vincristine is a commonly used antineoplastic drug and frequently causes neurotoxicity. Here the authors report a 4-year-old boy with acute lymphoblastic leukemia in whom vincristine-induced peripheral and cranial neuropathy developed during remission induction therapy. The patient seemed to benefit from pyridoxine and pyridostigmine therapy greatly and this therapy is recommended in patients with severe vincristine-induced neuropathy.
MeSH terms
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Antineoplastic Combined Chemotherapy Protocols / administration & dosage
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Antineoplastic Combined Chemotherapy Protocols / adverse effects
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
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Axonal Transport / drug effects
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Blepharoptosis / chemically induced
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Blepharoptosis / drug therapy
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Child, Preschool
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Cholinesterase Inhibitors / therapeutic use*
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Combined Modality Therapy
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Cranial Irradiation
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Cranial Nerve Diseases / chemically induced
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Cranial Nerve Diseases / drug therapy*
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Epilepsy, Tonic-Clonic / chemically induced
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Gait Disorders, Neurologic / chemically induced
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Gait Disorders, Neurologic / drug therapy
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Heart Arrest / chemically induced
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Heart Arrest / therapy
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Humans
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Male
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Neuroprotective Agents / therapeutic use*
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Peripheral Nervous System Diseases / chemically induced
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Peripheral Nervous System Diseases / drug therapy*
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Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / complications
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Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / drug therapy*
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Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / radiotherapy
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Pyridostigmine Bromide / therapeutic use*
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Pyridoxine / therapeutic use*
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Sensation Disorders / chemically induced
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Sensation Disorders / drug therapy
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Unconsciousness / chemically induced
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Vincristine / administration & dosage
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Vincristine / adverse effects*
Substances
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Cholinesterase Inhibitors
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Neuroprotective Agents
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Vincristine
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Pyridoxine
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Pyridostigmine Bromide