High innate production capacity of tumor necrosis factor-alpha and decline of handgrip strength in old age

Diana G Taekema; Rudi G J Westendorp; Marijke Frölich; Jacobijn Gussekloo

doi:10.1016/j.mad.2007.07.001

High innate production capacity of tumor necrosis factor-alpha and decline of handgrip strength in old age

Mech Ageing Dev. 2007 Sep;128(9):517-21. doi: 10.1016/j.mad.2007.07.001. Epub 2007 Jul 7.

Authors

Diana G Taekema¹, Rudi G J Westendorp, Marijke Frölich, Jacobijn Gussekloo

Affiliation

¹ Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands. [email protected]

PMID: 17714763
DOI: 10.1016/j.mad.2007.07.001

Abstract

Increased signaling of the pro-inflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) elicits apoptosis of skeletal muscle cells in various animal models. Within a population-based prospective follow up study of elderly people aged 85 years we show that a high innate production capacity of TNF-alpha precedes a steeper decline in muscle strength over time.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aged, 80 and over
Aging / blood*
Aging / immunology
C-Reactive Protein / metabolism
Female
Follow-Up Studies
Hand Strength*
Humans
Immunity, Innate*
Interleukins / blood
Male
Muscle Weakness / blood*
Muscle Weakness / immunology
Muscle Weakness / physiopathology
Prospective Studies
Time Factors
Tumor Necrosis Factor-alpha / blood*

Substances

Interleukins
Tumor Necrosis Factor-alpha
C-Reactive Protein