Mortality due to dapsone hypersensitivity syndrome complicating multi-drug therapy for leprosy in Nepal

Trop Doct. 2007 Jul;37(3):162-3. doi: 10.1258/004947507781524700.

Abstract

Dapsone is a component of multi-drug therapy (MDT) for the treatment of all types of leprosy. It is known that dapsone hypersensitivity syndrome (DHS) complicates the treatment in a proportion of patients. We performed a retrospective study of patients commenced on MDT between 1990 and 2006; 2% developed DHS and 0.25% died due to DHS.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Dapsone / administration & dosage
  • Dapsone / adverse effects*
  • Drug Hypersensitivity / epidemiology
  • Drug Hypersensitivity / etiology
  • Drug Hypersensitivity / mortality*
  • Drug Therapy, Combination
  • Female
  • Humans
  • Leprostatic Agents / administration & dosage
  • Leprostatic Agents / adverse effects*
  • Leprosy / drug therapy*
  • Leprosy / epidemiology
  • Male
  • Middle Aged
  • Nepal / epidemiology

Substances

  • Leprostatic Agents
  • Dapsone