Abstract
The N-amination of heterocyclic compounds 1a-k with O-benzoylhydroxylamine derivatives 5 was developed and demonstrated to be a superior alternative to existing N-amination methods. A structure-reactivity relationship study was performed on variously substituted O-benzoylhydroxylamine derivatives, leading to the discovery of the novel and more efficient aminating reagents 5h and 5i.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amination
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Anions
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Heterocyclic Compounds / chemical synthesis*
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Heterocyclic Compounds / chemistry
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Hydrolysis
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Hydroxylamines / chemistry*
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Isomerism
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Kinetics
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Molecular Structure
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Pyrroles / chemistry
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Triazines / chemistry
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Water / chemistry
Substances
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Anions
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Heterocyclic Compounds
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Hydroxylamines
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Pyrroles
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Triazines
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Water
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O-benzoylhydroxylamine