Dendrimeric poly(propylene-imines) as effective delivery agents for DNAzymes: toxicity, in vitro transfection and in vivo delivery

J Control Release. 2006 Nov 28;116(2):e26-8. doi: 10.1016/j.jconrel.2006.09.031.

Authors

F Tack¹, A Bakker, S Maes, N Dekeyser, M Bruining, C Elissen-Roman, M Janicot, H M Janssen, B F M De Waal, P M Fransen, X Lou, E W Meijer, A Arien, M E Brewster

Affiliation

¹ Oncology Discovery Research and Early Development, Johnson and Johnson Pharmaceutical Research and Development, Beerse, Belgium. [email protected] <[email protected]>

PMID: 17718951
DOI: 10.1016/j.jconrel.2006.09.031

No abstract available

MeSH terms

Cell Line, Tumor
DNA / administration & dosage
DNA / chemistry
DNA / pharmacokinetics
DNA, Catalytic / administration & dosage*
DNA, Catalytic / chemistry
DNA, Catalytic / pharmacokinetics
Dendrimers / administration & dosage*
Dendrimers / chemical synthesis
Dendrimers / chemistry
Dendrimers / pharmacokinetics
Drug Delivery Systems / methods
Female
Genes, myc
Humans
Oligonucleotides / administration & dosage*
Oligonucleotides / chemistry
Oligonucleotides / pharmacokinetics
Ovarian Neoplasms / genetics
Ovarian Neoplasms / metabolism
Ovarian Neoplasms / therapy
Polypropylenes / administration & dosage*
Polypropylenes / chemical synthesis
Polypropylenes / chemistry
Polypropylenes / pharmacokinetics
Transfection / methods*

Substances

DNA, Catalytic
Dendrimers
Oligonucleotides
Polypropylenes
poly(propyleneimine)
DNA