Value of Toxoplasma gondii detection in one hundred thirty-three placentas for the diagnosis of congenital toxoplasmosis

Pediatr Infect Dis J. 2007 Sep;26(9):845-6. doi: 10.1097/INF.0b013e318123e8d3.

Abstract

The placenta examination by polymerase chain reaction and mouse inoculation increased the sensitivity of the diagnosis of congenital toxoplasmosis at birth from 60% (use of serologic techniques on the newborn's blood only) to 75% (both serologic techniques and placental analysis). The specificity of Toxoplasma gondii detection in the placenta was 94.7%.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Anti-Infective Agents / therapeutic use
  • Child, Preschool
  • Female
  • Humans
  • Immunoglobulin G / blood
  • Immunoglobulin M / blood
  • Infant
  • Infant, Newborn
  • Mice
  • Placenta / parasitology*
  • Polymerase Chain Reaction
  • Pregnancy
  • Pyrimethamine / therapeutic use
  • Sensitivity and Specificity
  • Spiramycin / therapeutic use
  • Sulfadoxine / therapeutic use
  • Toxoplasma / drug effects
  • Toxoplasma / isolation & purification*
  • Toxoplasmosis, Congenital / drug therapy
  • Toxoplasmosis, Congenital / immunology
  • Toxoplasmosis, Congenital / parasitology*

Substances

  • Anti-Infective Agents
  • Immunoglobulin G
  • Immunoglobulin M
  • Spiramycin
  • Sulfadoxine
  • Pyrimethamine