Abstract
A series of 4-heterotricyclic substituted 1,4-dihydropyridines were prepared. The compounds were evaluated for inotropic, chronotropic and calcium antagonist properties. The tested compounds are fairly good as calcium antagonists, but exert potent selective bradycardic effects.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Aorta, Thoracic / drug effects
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Calcium Channel Blockers / pharmacology
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Dihydropyridines / chemical synthesis*
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Dihydropyridines / chemistry
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Dihydropyridines / pharmacology
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Female
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Guinea Pigs
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Heart Rate / drug effects*
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In Vitro Techniques
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Male
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Muscle Contraction / drug effects
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Muscle, Smooth, Vascular / drug effects
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Myocardial Contraction / drug effects
Substances
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Calcium Channel Blockers
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Dihydropyridines