Staying alive--naïve CD4(+) T cell homeostasis

Eur J Immunol. 2007 Sep;37(9):2367-9. doi: 10.1002/eji.200737721.

Abstract

The immune system must maintain a broad repertoire of naïve T cells in order to respond to the diverse range of pathogens that it will encounter over the course of a lifetime. Although it is known that contact with IL-7 is crucial for the survival of naïve T cells, the precise intracellular signals that mediate its effects remain obscure. An article in this issue of the European Journal of Immunology has found that IL-7 requires the coordinated action of multiple pathways to maintain naïve CD4(+) T cells.

Publication types

  • Comment
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • CD4-Positive T-Lymphocytes / immunology*
  • Cytokines / immunology
  • Homeostasis / immunology*
  • Immunity, Innate / immunology*

Substances

  • Cytokines