Abstract
(125)I-labeled anti-TAG-72 antibodies were applied in radioimmunoguided surgery (RIGS) to remove gross and occult tumors. It is challenging to handle (125)I-labeled materials. PET/CT image-guided surgery utilizes (18)FDG to monitor the biochemical activity of the tumor and to integrate pre- and postoperative imaging for complete tumor removal. PET/CT image-guided surgery only detects later stage disease. Fluorescence image-guided surgery using anti-TAG-72 antibodies may provide opportunities for intraoperative cancer detection of both gross and occult tumors.
MeSH terms
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Antibodies, Monoclonal / drug effects
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Antibodies, Neoplasm / drug effects
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Antigens, Neoplasm / immunology
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Colorectal Neoplasms / diagnostic imaging
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Colorectal Neoplasms / pathology
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Colorectal Neoplasms / surgery*
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Fluorescence
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Fluorodeoxyglucose F18
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Forecasting
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Gamma Cameras
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Glycoproteins / immunology
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Humans
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Iodine Radioisotopes
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Neoplasm Staging
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Positron-Emission Tomography*
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Radioimmunodetection* / trends
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Radiopharmaceuticals*
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Surgery, Computer-Assisted* / trends
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Survival Analysis
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Tomography, X-Ray Computed*
Substances
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Antibodies, Monoclonal
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Antibodies, Neoplasm
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Antigens, Neoplasm
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B72.3 antibody
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Glycoproteins
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Iodine Radioisotopes
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Radiopharmaceuticals
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tumor-associated antigen 72
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Fluorodeoxyglucose F18