Abstract
A template-based mnemonic has been developed for the enzyme monoamine oxidase from Aspergillus niger and has been used to successfully identify the alkaloid (+/-)-crispine A as a target for chemo-enzymatic deracemisation yielding the biologically active (R)-enantiomer in 97% e.e.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkaloids / chemistry*
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Alkaloids / metabolism
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Aspergillus niger / enzymology*
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Carduus / chemistry*
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Catalysis
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Isoquinolines / chemistry
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Isoquinolines / isolation & purification*
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Molecular Structure
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Monoamine Oxidase / chemistry
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Monoamine Oxidase / metabolism*
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Oxidation-Reduction
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Stereoisomerism
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Substrate Specificity
Substances
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Alkaloids
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Isoquinolines
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crispine A
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Monoamine Oxidase