Abstract
Female aged rats treated with nimodipine, a calcium-blocker dihydropyridine derivative, were submitted to a psychological-stress situation. Nimodipine at the doses of 3 and 6 mg/Kg antagonized the stress-related body-weight decrease and lethality. These findings seem to validate the role of Ca-mediated mechanisms in the physiopathology of stress and the protective effects of the Ca-blockers in the stress-related illnesses.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Age Factors
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Aggression / drug effects
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Animals
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Anxiety / etiology
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Avoidance Learning / drug effects*
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Calcium / physiology*
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Female
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Nimodipine / administration & dosage
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Nimodipine / pharmacology*
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Nimodipine / therapeutic use
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Rats
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Rats, Inbred Lew / psychology
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Stress, Psychological / drug therapy*
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Stress, Psychological / physiopathology
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Weight Loss / drug effects