Abstract
We assessed the percentage of endothelial progenitor cells (EPCs) in the peripheral blood of a patient with POEMS with elevated VEGF plasma levels. High VEGF plasma levels were associated with increased EPC concentration and treatment with an anti-VEGF antibody induced a consensual decrease of both parameters. In vitro cultures of the patient BM cells suggested that the stromal compartment could be responsible for VEGF overproduction.
MeSH terms
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Angiogenesis Inhibitors / therapeutic use
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Antibodies, Monoclonal / therapeutic use
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Antibodies, Monoclonal, Humanized
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Bevacizumab
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Cell Movement*
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Cells, Cultured
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Endothelium, Vascular / cytology*
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Endothelium, Vascular / metabolism
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Humans
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Neovascularization, Pathologic
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POEMS Syndrome / blood*
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POEMS Syndrome / drug therapy
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POEMS Syndrome / pathology
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Stem Cells / cytology*
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Stem Cells / metabolism
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Vascular Endothelial Growth Factor A / pharmacology*
Substances
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Angiogenesis Inhibitors
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Antibodies, Monoclonal
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Antibodies, Monoclonal, Humanized
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VEGFA protein, human
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Vascular Endothelial Growth Factor A
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Bevacizumab