Long-latency auditory event-related potentials in schizophrenia and in bipolar and unipolar affective disorder

Psychol Med. 1991 Nov;21(4):867-79. doi: 10.1017/s003329170002986x.

Abstract

Long-latency auditory event-related potentials were examined in 96 subjects with schizophrenia, 99 with bipolar affective disorder and 48 with major depressive (unipolar) disorder, and compared with 32 in-patient and 213 normal controls. The latency of the P3 component was significantly greater in the schizophrenic and bipolar subjects compared to other groups. The difference was stable with respect to clinical state at the time of testing and was not due to age differences or the effect of psychotropic medications. The results support the clinical distinction between bipolar and unipolar affective disorders, but also show that P3 change is not specific to schizophrenia and found in bipolar but not unipolar affective disorder.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Attention / drug effects
  • Attention / physiology
  • Bipolar Disorder / diagnosis*
  • Bipolar Disorder / drug therapy
  • Bipolar Disorder / physiopathology*
  • Borderline Personality Disorder / diagnosis
  • Borderline Personality Disorder / drug therapy
  • Borderline Personality Disorder / physiopathology
  • Cerebral Cortex / drug effects
  • Cerebral Cortex / physiopathology
  • Depressive Disorder / diagnosis*
  • Depressive Disorder / drug therapy
  • Depressive Disorder / physiopathology*
  • Electroencephalography / drug effects
  • Electroencephalography / instrumentation
  • Female
  • Humans
  • Male
  • Middle Aged
  • Neurotic Disorders / diagnosis
  • Neurotic Disorders / drug therapy
  • Neurotic Disorders / physiopathology
  • Personality Disorders / diagnosis
  • Personality Disorders / drug therapy
  • Personality Disorders / physiopathology
  • Pitch Discrimination / drug effects
  • Pitch Discrimination / physiology*
  • Psychiatric Status Rating Scales
  • Psychotropic Drugs / therapeutic use
  • Reaction Time / drug effects
  • Reaction Time / physiology*
  • Schizophrenia / diagnosis*
  • Schizophrenia / drug therapy
  • Schizophrenia / physiopathology*
  • Schizophrenic Psychology*
  • Signal Processing, Computer-Assisted / instrumentation

Substances

  • Psychotropic Drugs