The value of computed tomography-guided percutaneous lung biopsy for diagnosis of invasive fungal infection in immunocompromised patients

Clin Infect Dis. 2007 Oct 1;45(7):e101-4. doi: 10.1086/521245. Epub 2007 Aug 20.

Abstract

We assessed Calcofluor white staining, Aspergillus polymerase chain reaction, and a galactomannan enzyme immunoassay for diagnosis of fungal infection with use of computed tomography-guided percutaneous lung biopsy specimens obtained from 61 patients. The sensitivity and specificity of computerized tomography, Aspergillus polymerase chain reaction, and galactomannan enzyme immunoassay were 100% and 50%, 100% and 86%, and 88% and 94%, respectively.

Publication types

  • Evaluation Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aspergillosis / diagnosis*
  • Aspergillus / genetics*
  • Benzenesulfonates
  • Biopsy / methods*
  • Contrast Media
  • False Positive Reactions
  • Female
  • Galactose / analogs & derivatives
  • Humans
  • Immunocompromised Host*
  • Immunoenzyme Techniques / methods
  • Lung Diseases, Fungal / diagnosis*
  • Male
  • Mannans / analysis*
  • Middle Aged
  • Polymerase Chain Reaction / methods
  • Prospective Studies
  • Sensitivity and Specificity
  • Tomography, X-Ray Computed / methods

Substances

  • Benzenesulfonates
  • Contrast Media
  • Mannans
  • galactomannan
  • C.I. Fluorescent Brightening Agent 28
  • Galactose