Influence of haemodialysis on high-sensitivity C-reactive protein, lipoprotein(a), apolipoproteins A and B

Giuseppe Lippi; Nicola Tessitore; Gian Luca Salvagno; Valeria Bedogna; Antonella Bassi; Martina Montagnana; Antonio Lupo; Gian Cesare Guidi

doi:10.1016/j.clinbiochem.2007.07.007

Influence of haemodialysis on high-sensitivity C-reactive protein, lipoprotein(a), apolipoproteins A and B

Clin Biochem. 2007 Nov;40(16-17):1336-8. doi: 10.1016/j.clinbiochem.2007.07.007. Epub 2007 Aug 10.

Authors

Giuseppe Lippi¹, Nicola Tessitore, Gian Luca Salvagno, Valeria Bedogna, Antonella Bassi, Martina Montagnana, Antonio Lupo, Gian Cesare Guidi

Affiliation

¹ Sezione di Chimica Clinica, Dipartimento di Scienze Morfologico-Biomediche, Università degli Studi di Verona, Ospedale Policlinico G.B. Rossi, Piazzale Scuro, 10, 37121-Verona, Italy. [email protected]

PMID: 17826754
DOI: 10.1016/j.clinbiochem.2007.07.007

Abstract

Objectives: There is debate on the influence of haemodialysis (HD) on lipoprotein(a).

Design and methods: Lp(a), apo A, apo B and high-sensitivity C-reactive protein (hs-CRP) were measured in 46 patients pre- and post-HD.

Results: The median Lp(a) concentration significantly decreased post-HD (106 vs. 145 mg/L, p<0.001). No significant variations were observed for apo A, apo B and hs-CRP. Comparable results were observed with high- and low-flux membranes.

Conclusion: HD is effective in lowering Lp(a).

MeSH terms

Aged
Aged, 80 and over
Apolipoproteins / blood*
Apolipoproteins A / blood*
Apolipoproteins B / blood*
C-Reactive Protein / analysis*
Female
Humans
Kidney Failure, Chronic / blood
Kidney Failure, Chronic / therapy*
Male
Middle Aged
Renal Dialysis*

Substances

Apolipoproteins
Apolipoproteins A
Apolipoproteins B
C-Reactive Protein