Abstract
Synthesis, pharmacology, and pharmacokinetic profiles of (1R, 2S)-4-(2-cyano-cyclohexyl-oxy)-2-trifluoromethyl-benzonitrile are reported. This compound demonstrated remarkable potency for stimulating hair growth in a male C3H mouse model as well as reducing sebum production in the male Syrian hamster ear model.
MeSH terms
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Androgen Antagonists / pharmacology*
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Animals
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Cricetinae
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Hair / growth & development*
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Hydrocarbons, Fluorinated / pharmacokinetics
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Hydrocarbons, Fluorinated / pharmacology*
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Male
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Mesocricetus
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Mice
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Models, Molecular
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Nitriles / pharmacokinetics
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Nitriles / pharmacology*
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Sebum*
Substances
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(1R,2S)-4-(2-cyano-cyclohexyl-oxy)-2-trifluoromethyl-benzonitrile
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Androgen Antagonists
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Hydrocarbons, Fluorinated
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Nitriles