A 25-year-old woman was admitted to the neurology department because of sudden onset of weakness of her left upper and lower extremities. Cardiac auscultation revealed an extra sound. Transesophageal echocardiography showed a huge mobile fleshy mass on the atrial side of anterior mitral leaflet protruding into the left ventricle during diastole. A large irregularly shaped mass resembling a 'cluster of grapes' was found on the atrial side of anterior mitral leaflet. The mass was excised and mitral valve was repaired. Histology was diagnostic for myxoma. Six months clinical and echocardiographic follow-up was normal and did not show any recurrence of tumor.