Abstract
Bioassay-directed fractionation of an ethanolic extract of the galls of Sapindus mukorossi has resulted in the isolation of two new tirucallane-type triterpenoid saponins, sapinmusaponins Q (1) and R (2), along with three known oleanane-type triterpenoid saponins (3-5). Their structures were elucidated on the basis of spectroscopic analysis and chemical hydrolysis. Biological evaluation showed that both sapinmusaponins Q and R demonstrated more potent anti-platelet aggregation activity than aspirin.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Carbohydrate Conformation
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Carbohydrate Sequence
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Chromatography, High Pressure Liquid
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Chromatography, Thin Layer
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Hydrolysis
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L-Lactate Dehydrogenase / metabolism
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Magnetic Resonance Spectroscopy
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Molecular Sequence Data
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Plant Extracts / analysis
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Plant Tumors*
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Platelet Aggregation Inhibitors / isolation & purification*
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Platelet Aggregation Inhibitors / pharmacology*
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Sapindus / chemistry*
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Saponins / isolation & purification*
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Saponins / pharmacology*
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Spectrophotometry, Infrared
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Triterpenes / isolation & purification*
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Triterpenes / pharmacology*
Substances
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Plant Extracts
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Platelet Aggregation Inhibitors
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Saponins
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Triterpenes
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sapinmusaponin I
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sapinmusaponin Q
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L-Lactate Dehydrogenase