Effect of intracanalicular collagen implants on the absorption of topically applied sodium fluorescein

Cornea. 1991 Nov;10(6):516-8. doi: 10.1097/00003226-199111000-00009.

Abstract

Absorbable intracanalicular collagen implants were placed in both canaliculi of one eye of nine human volunteers. The other eye served as a control. Twenty-four hours later 2% sodium fluorescein was placed into both conjunctival sacs. Serial corneal fluorescein concentrations were measured with a scanning ocular fluorophotometer from 2 to 90 min after fluorescein administration. The mean corneal fluorescein concentration averaged over all time points was greater in 7 of 9 eyes with collagen implants compared to unimplanted controls. When the data from each subject were analyzed collectively, the mean corneal fluorescein concentration in the implanted eyes (1,218 micrograms/ml +/- SEM 83) was significantly greater (p less than 0.001) than the mean concentration in the control eyes (823 micrograms/ml +/- SEM 83). The use of absorbable intracanalicular collagen implants may increase the bioavailability of topically applied ocular solutions.

MeSH terms

  • Absorption
  • Administration, Topical
  • Adult
  • Biological Availability
  • Collagen*
  • Cornea / metabolism*
  • Female
  • Fluorescein
  • Fluoresceins / administration & dosage
  • Fluoresceins / pharmacokinetics*
  • Fluorophotometry
  • Humans
  • Lacrimal Duct Obstruction / metabolism*
  • Male
  • Ophthalmic Solutions / pharmacokinetics
  • Prostheses and Implants*

Substances

  • Fluoresceins
  • Ophthalmic Solutions
  • Collagen
  • Fluorescein