Abstract
Dendritic cells are central to the generation of both immunity and tolerance. This review focuses on the alterations in the functions of dendritic cells in aged and its consequences on both tolerance and immunity. We have discussed certain mechanisms responsible for the defective dendritic cell function associated with aging.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Aging / immunology*
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Animals
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Antigens / immunology
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Cellular Senescence / immunology*
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Cytokines / immunology
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Cytokines / metabolism
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Dendritic Cells / immunology*
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Dendritic Cells / physiology
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Humans
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Immune Tolerance*
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Immunity*
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Immunity, Innate
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Protein Kinases / metabolism
Substances
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Antigens
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Cytokines
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Protein Kinases