A dual near-infrared pH fluorescent probe and its application in imaging of HepG2 cells

Chem Commun (Camb). 2007 Sep 28:(36):3726-8. doi: 10.1039/b707173f. Epub 2007 Jul 9.

Abstract

A dual near-infrared pH fluorescent probe has been designed, synthesized and applied to HepG2 cells, with a pK(a) value of 5.14 under acidic conditions and 11.31 under basic conditions, which is valuable for studying acidic organelles in living cells and pH changes in chemical systems.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Fluorescent Dyes / chemical synthesis*
  • Glucose Transporter Type 1*
  • Humans
  • Hydrogen-Ion Concentration
  • Kinetics
  • Molecular Probes
  • Molecular Structure
  • Spectroscopy, Near-Infrared / methods

Substances

  • Fluorescent Dyes
  • Glucose Transporter Type 1
  • Molecular Probes
  • SLC2A1 protein, human