A small-molecule antagonist of the hedgehog signaling pathway

Chembiochem. 2007 Nov 5;8(16):1916-9. doi: 10.1002/cbic.200700403.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alcohol Dehydrogenase / antagonists & inhibitors
  • Alcohol Dehydrogenase / chemistry
  • Alcohol Dehydrogenase / metabolism
  • Animals
  • Cell Line, Tumor
  • Cell Proliferation / drug effects
  • Dose-Response Relationship, Drug
  • Gene Expression Regulation / drug effects
  • Gene Expression Regulation / genetics
  • Hedgehog Proteins / antagonists & inhibitors*
  • Hedgehog Proteins / chemistry
  • Hedgehog Proteins / metabolism
  • Heterocyclic Compounds, 2-Ring / administration & dosage
  • Heterocyclic Compounds, 2-Ring / chemistry
  • Heterocyclic Compounds, 2-Ring / pharmacology*
  • Humans
  • Kruppel-Like Transcription Factors / antagonists & inhibitors
  • Kruppel-Like Transcription Factors / genetics
  • Kruppel-Like Transcription Factors / metabolism
  • Luciferases / drug effects
  • Luciferases / metabolism
  • Mesenchymal Stem Cells / drug effects
  • Mesenchymal Stem Cells / enzymology
  • Mice
  • Mice, Nude
  • Molecular Structure
  • Molecular Weight
  • RNA, Messenger / drug effects
  • RNA, Messenger / genetics
  • Reverse Transcriptase Polymerase Chain Reaction / methods
  • Signal Transduction / drug effects*
  • Signal Transduction / physiology
  • Structure-Activity Relationship
  • Thiazoles / administration & dosage
  • Thiazoles / chemistry
  • Thiazoles / pharmacology*
  • Xenograft Model Antitumor Assays
  • Zinc Finger Protein GLI1

Substances

  • Gli1 protein, mouse
  • Hedgehog Proteins
  • Heterocyclic Compounds, 2-Ring
  • JK184
  • Kruppel-Like Transcription Factors
  • RNA, Messenger
  • Thiazoles
  • Zinc Finger Protein GLI1
  • Adh7 protein, mouse
  • Alcohol Dehydrogenase
  • Luciferases