Abstract
The terrestrial Streptomyces sp. isolate GW6225 afforded julichrome Q 6 glucuronide ( 9), the first monomeric member of the julimycin-B complex, and additionally the julichromes Q 1.2 ( 7a), Q 1.5 ( 7b), and Q 3.5 ( 8), which were fully characterized by 2D NMR spectra. Additional new microbial compounds were 4-acetylchrysophanol ( 6a) and N-phenyl-beta-naphthylamine ( 10). The isomeric N-phenyl-alpha-naphthylamine ( 11) was found in the marine Streptomyces sp. B8335 and was also characterized. The high antibiotic activity of Streptomyces sp. GW6225 extracts was probably due to the thiazolyl cyclopeptide nosiheptide.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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1-Naphthylamine / analogs & derivatives
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1-Naphthylamine / chemistry
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2-Naphthylamine / analogs & derivatives
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2-Naphthylamine / chemistry
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Bacteria / drug effects
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Candida albicans / drug effects
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Chlorella / drug effects
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Drug Screening Assays, Antitumor
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Factor VIIa
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Glucuronates / chemistry
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Glucuronates / isolation & purification*
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Glucuronates / pharmacology
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Marine Biology
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Microbial Sensitivity Tests
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Molecular Structure
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Naphthalenes / chemistry
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Naphthalenes / isolation & purification*
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Naphthalenes / pharmacology
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Nuclear Magnetic Resonance, Biomolecular
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Recombinant Proteins
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Streptomyces / chemistry*
Substances
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Glucuronates
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Naphthalenes
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Recombinant Proteins
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julichrome Q6 glucuronide
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neozone
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N-phenyl-1-naphthylamine
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1-Naphthylamine
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recombinant FVIIa
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2-Naphthylamine
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Factor VIIa