DISC1 puts the brakes on neurogenesis

Cell. 2007 Sep 21;130(6):981-3. doi: 10.1016/j.cell.2007.09.004.

Abstract

The gene DISC1 (Disrupted-in-Schizophrenia 1) is a leading candidate gene for schizophrenia. In this issue, Duan et al. (2007) present evidence implicating DISC1 in the maturation and integration of newly generated neurons in the adult mouse hippocampus. Surprisingly, DISC1 appears to have opposite effects on neurogenesis during development and in adulthood.

Publication types

  • Comment

MeSH terms

  • Animals
  • Carrier Proteins / genetics
  • Carrier Proteins / metabolism
  • Cell Differentiation
  • Cell Lineage
  • Cell Movement
  • Cell Proliferation
  • Cell Size
  • Dendrites / metabolism
  • Dentate Gyrus / metabolism
  • Dentate Gyrus / pathology
  • Genotype
  • Hippocampus / embryology
  • Hippocampus / growth & development
  • Hippocampus / metabolism*
  • Hippocampus / pathology
  • Mice
  • Morphogenesis
  • Nerve Tissue Proteins / deficiency
  • Nerve Tissue Proteins / genetics
  • Nerve Tissue Proteins / metabolism*
  • Neurons / metabolism*
  • Neurons / pathology
  • Phenotype
  • Schizophrenia / genetics
  • Schizophrenia / metabolism*
  • Schizophrenia / physiopathology
  • Stem Cells / metabolism*
  • Stem Cells / pathology
  • Synapses / metabolism*
  • Synapses / pathology
  • Time Factors

Substances

  • Carrier Proteins
  • Disc1 protein, mouse
  • Ndel1 protein, mouse
  • Nerve Tissue Proteins