Abstract
We have recently reported that nobiletin, a citrus flavonoid, improves impaired memory in olfactory-bulbectomized (OBX) mice, which have been widely utilized as a useful paradigm that shares some major clinical features of Alzheimer's disease. Here, we examined the effects of nobiletin on OBX-induced cholinergic neurodegeneration in mice. OBX mice showed reduced acetylcholinesterase (AChE) staining and choline acetyltransferase (ChAT) expression in the hippocampus. An 11-day administration of nobiletin rescued OBX-induced decrease in the density of AChE-staining and ChAT expression in the hippocampus. These results suggest that nobiletin rescues OBX-induced cholinergic neurodegeneration, accompanied by improvement of impaired memory in OBX mice.
MeSH terms
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Acetylcholinesterase / metabolism
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Animals
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Antioxidants / chemistry
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Antioxidants / pharmacology
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Antioxidants / therapeutic use
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Choline O-Acetyltransferase / metabolism
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Cholinergic Fibers / drug effects
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Cholinergic Fibers / metabolism
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Cholinergic Fibers / pathology
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Citrus / chemistry*
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Flavones / chemistry
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Flavones / pharmacology*
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Flavones / therapeutic use
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Flavonoids / chemistry
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Flavonoids / pharmacology
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Flavonoids / therapeutic use
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Male
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Memory Disorders / drug therapy*
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Mice
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Models, Anatomic
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Molecular Structure
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Nerve Degeneration / metabolism
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Nerve Degeneration / pathology
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Nerve Degeneration / prevention & control*
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Olfactory Bulb / physiopathology
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Olfactory Bulb / surgery*
Substances
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Antioxidants
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Flavones
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Flavonoids
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nobiletin
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Choline O-Acetyltransferase
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Acetylcholinesterase