Abstract
Because the embryopathy associated with maternal warfarin use seems dose-dependent, some physicians advocate low-dose warfarin for pregnant women requiring anticoagulation. The current case, however, highlights that optic nerve dysfunction (as well as other signs of warfarin embryopathy) can occur after low-dose maternal warfarin exposure.
MeSH terms
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Abnormalities, Drug-Induced
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Anticoagulants / administration & dosage
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Anticoagulants / adverse effects*
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Anticoagulants / therapeutic use
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Dose-Response Relationship, Drug
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Face / abnormalities
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Female
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Humans
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Infant
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Nails, Malformed / chemically induced
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Nails, Malformed / pathology
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Optic Nerve Diseases / chemically induced*
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Pregnancy
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Pregnancy Complications, Cardiovascular / drug therapy
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Pregnancy Trimester, First
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Prenatal Exposure Delayed Effects*
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Venous Thrombosis / drug therapy
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Warfarin / administration & dosage
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Warfarin / adverse effects*
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Warfarin / therapeutic use