Complex multidrug therapy in a patient with pulmonary hypertension before and after orthotopic heart transplantation. A case report

J Cardiovasc Med (Hagerstown). 2007 Nov;8(11):950-2. doi: 10.2459/JCM.0b013e328013fa50.

Abstract

Pulmonary arterial hypertension represents an absolute contraindication for heart transplantation. We report the case of a 30-year-old man with end-stage heart failure due to restrictive cardiomyopathy and pulmonary arterial hypertension. A complex multidrug therapy improved pulmonary haemodynamics to the point that orthotopic heart transplantation could be carried out. At 18-month follow-up after heart transplantation, the patient's cardiac function made a full recovery. Larger prospective studies are warranted to support these results.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antihypertensive Agents / administration & dosage*
  • Bosentan
  • Cardiac Catheterization
  • Cardiomyopathy, Restrictive / complications
  • Cardiomyopathy, Restrictive / physiopathology
  • Contraindications
  • Drug Therapy, Combination
  • Epoprostenol / administration & dosage*
  • Heart Failure / etiology
  • Heart Failure / physiopathology
  • Heart Failure / surgery*
  • Heart Transplantation*
  • Humans
  • Hypertension, Pulmonary / complications
  • Hypertension, Pulmonary / drug therapy*
  • Hypertension, Pulmonary / physiopathology
  • Male
  • Sulfonamides / administration & dosage*

Substances

  • Antihypertensive Agents
  • Sulfonamides
  • Epoprostenol
  • Bosentan