Abstract
In the course of our research program to develop novel muscarinic receptor antagonists for the treatment of COPD, new tropane carbamate derivatives were identified as potent anti-muscarinic agents. The synthesis, structure-activity relationships and pharmacological evaluation that led to the identification of compound 5o, are described.
MeSH terms
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Animals
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Bridged Bicyclo Compounds, Heterocyclic / chemical synthesis*
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Bridged Bicyclo Compounds, Heterocyclic / chemistry
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Bridged Bicyclo Compounds, Heterocyclic / pharmacology
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Bronchodilator Agents / chemical synthesis
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Bronchodilator Agents / chemistry
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Bronchodilator Agents / pharmacology
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Carbamates / chemical synthesis*
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Carbamates / chemistry
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Carbamates / pharmacology
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Drug Evaluation, Preclinical
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Inhibitory Concentration 50
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Mice
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Molecular Structure
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Muscarinic Antagonists* / chemical synthesis
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Muscarinic Antagonists* / chemistry
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Muscarinic Antagonists* / pharmacology
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Pulmonary Disease, Chronic Obstructive / therapy
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Receptors, Muscarinic / drug effects*
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Tropanes / chemical synthesis*
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Tropanes / chemistry
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Tropanes / pharmacology
Substances
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Bridged Bicyclo Compounds, Heterocyclic
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Bronchodilator Agents
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Carbamates
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Muscarinic Antagonists
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Receptors, Muscarinic
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Tropanes