Elevated concentrations of soluble adhesion molecules and large platelets in diabetic patients: are they markers of vascular disease and diabetic nephropathy?

Clin Appl Thromb Hemost. 2007 Oct;13(4):391-7. doi: 10.1177/1076029607303615.

Abstract

P-selectin, E-selectin, and mean platelet volume are markers associated with platelet reactivity that have been demonstrated to be increased in diabetes. We were particularly interested to see if there was a difference in mean platelet volume and selectins between diabetics and nondiabetics, and in diabetics with and without nephropathy, and whether there was a correlation between mean platelet volume and selectins. One hundred and fourteen diabetic patients and 31 healthy controls were investigated. Plasma levels of P-selectin and E-selectin were higher in the diabetic group than in controls (P = .001 and P = .007, respectively) and in diabetic patients with proteinuria than in patients without proteinuria (P = .002 and P = .004, respectively). Protein excretion was lower in patients with low mean platelet volume values (P = .004). In conclusion, elevated platelet volume and high selectin values may play a role in the development of vasculopathies and complications in diabetes mellitus. Further studies are needed to prove these results.

MeSH terms

  • Aged
  • Biomarkers / blood
  • Blood Platelets / pathology*
  • Case-Control Studies
  • Coronary Artery Disease / blood
  • Coronary Artery Disease / complications
  • Diabetes Mellitus, Type 2 / blood*
  • Diabetic Angiopathies / blood
  • Diabetic Nephropathies / blood
  • Diabetic Retinopathy / blood
  • E-Selectin / blood*
  • Female
  • Humans
  • Male
  • Middle Aged
  • P-Selectin / blood*
  • Proteinuria / blood
  • Solubility

Substances

  • Biomarkers
  • E-Selectin
  • P-Selectin