Abstract
Several recent studies have found a conserved microRNA (miRNA) family, the miR-34s, to be direct transcriptional targets of p53. miR-34 activation can recapitulate elements of p53 activity, including induction of cell-cycle arrest and promotion of apoptosis, and loss of miR-34 can impair p53-mediated cell death. These data reinforce the growing awareness that non-coding RNAs are key players in tumour development by placing miRNAs in a central role in a well-known tumour-suppressor network.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
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Review
MeSH terms
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Animals
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Apoptosis / genetics
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Apoptosis / physiology
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Caenorhabditis elegans / genetics
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Caenorhabditis elegans / physiology
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Caenorhabditis elegans Proteins / physiology
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Cell Division / genetics
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Cell Division / physiology
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Cell Line, Tumor
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Cell Transformation, Neoplastic / genetics*
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Gene Expression Regulation / genetics
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Gene Expression Regulation / physiology*
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Humans
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Mice
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MicroRNAs / genetics
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MicroRNAs / physiology*
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Neoplasms / genetics
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Oncogene Proteins / physiology
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Proto-Oncogene Proteins / physiology
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RNA Interference / physiology
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RNA, Helminth / physiology
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Tumor Suppressor Protein p53 / physiology*
Substances
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Caenorhabditis elegans Proteins
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MicroRNAs
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Oncogene Proteins
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Proto-Oncogene Proteins
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RNA, Helminth
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Tumor Suppressor Protein p53