Abstract
The styrylpyrone, goniodiol-7-monoacetate [1] [6R-(7R,8R-dihydro-7-acetoxy-8-hydroxystyryl)-5, 6-dihydro-2-pyrone], has been isolated from Goniothalamus amuyon, and its detailed molecular structure has been determined by X-ray crystallographic analysis. Goniodiol-7-monoacetate showed potent (ED50 values less than 0.1 microgram/ml) cytotoxicities against KB, P-388, RPMI, and TE671 tumor cells.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antineoplastic Agents, Phytogenic* / chemistry
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Antineoplastic Agents, Phytogenic* / isolation & purification
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Crystallization
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Drug Screening Assays, Antitumor
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Humans
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Leukemia P388 / drug therapy
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Molecular Structure
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Plants, Medicinal*
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Pyrones / chemistry
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Pyrones / isolation & purification
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Pyrones / pharmacology*
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Styrenes / chemistry
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Styrenes / isolation & purification
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Styrenes / pharmacology*
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Tumor Cells, Cultured
Substances
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Antineoplastic Agents, Phytogenic
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Pyrones
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Styrenes
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goniodiol-7-monoacetate