Vilsmeier-Haack reactions of 2-arylamino-3-acetyl-5,6-dihydro-4H-pyrans toward the synthesis of highly substituted pyridin-2(1H)-ones

J Org Chem. 2007 Oct 26;72(22):8593-6. doi: 10.1021/jo7015482. Epub 2007 Oct 4.

Abstract

A facile and efficient one-pot synthesis of highly substituted pyridin-2(1H)-ones was developed via Vilsmeier-Haack reactions of readily available enaminones, 2-arylamino-3-acetyl-5,6-dihydro-4H-pyrans, and a mechanism involving sequential ring-opening, haloformylation, and intramolecular nucleophilic cyclization reactions is proposed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Molecular Structure
  • Pyrans / chemistry*
  • Pyridones / chemical synthesis*
  • Pyridones / chemistry
  • Stereoisomerism

Substances

  • Pyrans
  • Pyridones