Abstract
Interleukin-1 receptor-associated kinase-4 (IRAK-4), a member of the IRAK family, plays an essential role in Toll-like receptor- and IL-1 receptor-mediated signaling. We briefly review inherited human IRAK-4 deficiency, a recently described primary immunodeficiency leading to recurrent, invasive, pyogenic bacteria infection, and invasive pneumococcal disease in particular.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Humans
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Immunologic Deficiency Syndromes / complications
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Immunologic Deficiency Syndromes / genetics*
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Interleukin-1 Receptor-Associated Kinases / deficiency*
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Interleukin-1 Receptor-Associated Kinases / genetics
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Pneumococcal Infections / immunology*
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Staphylococcal Infections / immunology*
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Staphylococcus aureus
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Streptococcus pneumoniae
Substances
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Interleukin-1 Receptor-Associated Kinases